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KMID : 1123920030170041059
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 4 p.1059 ~ p.1064
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Study on antitumor activity of Chinese and Korean Oldenlandiae Herba and its effective compound
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Lee Hyo-Jeong
Song Gyu-Yong
Ra Jeong-Chan
Ahn Kyoo-Suk
Kim Sung-Hoon
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Abstract
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Oldenlandiae Herba has been used for the prevention or treatment of cancer in oriental medicine for years. Experimentally its antitumor activity was reported. However, in order to develop new Korean original plants. we tried to study the antitumor activity of Chinese and Korean origin Oldenlandiae Herba. We first evaluated the cytotoxicity of Oldenlandiae Herba originated from China and Korea on HT1080, U937 and SK-mel tumor cells. MeOH extract of Chinese Oldelandiae Herba was more effective than MeOH extract of Korean Oldenlandiae Herba. Approixmately IC50 of two species of Oldelandiae Herba was 380-450 ug/ml. For evaluation of antiangiogenic activity, proliferation assay with HUVECs(Human umblical vein endothelial cells) was done with three samples. Chinese Herba and Korean Herba and root. Korean root and herba was more effective than Chinese Herba. Thus, we found Korean Oldenlandiae was more effective on angigenic activity than Chiness Oldenlandiae. In an anlytical study on effective compounds from Oldenlandiae, the spot of ursolic acid was more marked by Korean Oldenlandiae than by Chinese Oldenlandiae. whereas the spot of asperuloside was more pronounced by Chinese Oldenlandiaethan by Korean Oldenlandiae by TLC analysis.
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KEYWORD
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Chinese Oldenlandiae Herba, Korean Oldenlandiae Herba, Korean Oldenlandiae root, cytotoxicity, proliferation, TLC
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